Change detection as an interdisciplinary discipline in the field of computer vision and remote sensing at present has been receiving extensive attention and research. Due to the rapid development of society, the geographic information captured by remote sensing satellites is changing faster and more complex, which undoubtedly poses a higher challenge and highlights the value of change detection tasks. We propose MFDS-Net: Multi-Scale Feature Depth-Supervised Network for Remote Sensing Change Detection with Global Semantic and Detail Information (MFDS-Net) with the aim of achieving a more refined description of changing buildings as well as geographic information, enhancing the localisation of changing targets and the acquisition of weak features. To achieve the research objectives, we use a modified ResNet_34 as backbone network to perform feature extraction and DO-Conv as an alternative to traditional convolution to better focus on the association between feature information and to obtain better training results. We propose the Global Semantic Enhancement Module (GSEM) to enhance the processing of high-level semantic information from a global perspective. The Differential Feature Integration Module (DFIM) is proposed to strengthen the fusion of different depth feature information, achieving learning and extraction of differential features. The entire network is trained and optimized using a deep supervision mechanism.The experimental outcomes of MFDS-Net surpass those of current mainstream change detection networks. On the LEVIR dataset, it achieved an F1 score of 91.589 and IoU of 84.483, on the WHU dataset, the scores were F1: 92.384 and IoU: 86.807, and on the GZ-CD dataset, the scores were F1: 86.377 and IoU: 76.021. The code is available at this https URL